040214 - Arnes
April 17, 2014

Volume 36 | Number 6

Obesity: Study Shows it May be Your Destiny


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Cheryl Walker, Ph.D., and a team of researchers have found that obesity may be innate.

 

By Holly Lambert  |  Texas A&M Institute of Biosciences and Technology

Research from the Texas A&M Health Science Center’s Institute of Biosciences and Technology found the likelihood of adults developing obesity may be determined before birth.

With grant funding from the National Institute of Environmental Health Sciences, one of the National Institutes of Health, Cheryl Walker, Ph.D., director of Texas A&M’s Institute of Biosciences and Technology, and a team of colleagues from across Houston’s Texas Medical Center are focusing on how the interaction between genes, the epigenome and the environment can increase risk for disease.

“The DNA we inherit is like computer hardware. What runs the ‘computer’ is the software – the epigenome. In early life, as embryos or infants, this epigenetic programming is being ‘installed’ on the genome of developing cells and tissues,” Walker explained. “Just like a computer, if the epigenetics – or software – isn’t installed correctly, the computer – or DNA – doesn’t work optimally.”

During this time in utero development and epigenetic programming, Mother Nature steps in and prepares the developing fetus to adapt and survive in its future environment.

“If while a woman is pregnant, her environment is nutrient-poor, there are cues given to the developing fetus and the epigenetic software modifies slightly so that after the child is born, he or she is able to survive in an environment where food is in short supply,” Walker said.

Sometimes, however, there is a disconnect between the cues given to the fetus and the actual environment. This disconnect can increase risk in adulthood for metabolic diseases, including obesity, diabetes, cardiovascular disease and cancer.

“If the programming tells the developing child that the environment is nutrient-poor and the child is born into a nutrient-rich environment, that causes a disconnect and results in a greater risk for disease,” Walker says.

A second area of the research focuses on environmental chemicals, specifically endocrine disrupting chemicals, which are found in many everyday products, including plastic bottles, metal food cans, detergents, flame-retardants and pesticides. This study is the first to look at the effect endocrine disrupting chemicals have on the liver, the most central organ in total body nutrition.

“Results show even a short exposure to endocrine disrupting chemicals early in life can disrupt the ‘install’ of the epigenetic software, causing a ‘reprogramming’ of the epigenome and increasing susceptibility to disease in adulthood,” Walker said.

“Early life development
is such a critical time
for ‘installation’ of
epigenetic programming
that is carried with us
throughout life.”

    - Cheryl Walker, Ph.D.    

In a complementing study, Walker and her team used a rodent model to study the long-term effects of exposure to endocrine disrupting chemicals early in life. Results show that animals exposed to endocrine disrupting chemicals shortly after birth exhibited life-long changes in their epigenome. As a result, they were at much greater risk for uterine cancer as adults and also became obese. If these animals’ calories were restricted by 30 percent, the risk of cancer decreased dramatically.

The findings illustrate that lifestyle interventions can potentially reverse the bad “reprogramming” by endocrine disrupting chemicals to decrease the risk of disease in adulthood.

The team plans to follow test subjects in the current study throughout life, focusing on how the endocrine disrupters are “talking” to the epigenetic software that causes those animals to become obese. The findings may have greater implications for the future of obesity research.

“First, it will be important to ensure vulnerable children, infants, and those still in the womb are not exposed to endocrine disrupting chemicals,” Walker said. “Secondly, research can move toward pinpointing specific genes that are the target for this programming and consequently develop biomarkers to identify individuals that are at a potential higher risk for disease.”

Preliminary data in this area is promising. The researchers may have identified a specific gene, a master regulator of metabolism, which seems to be the target of the epigenetic programming. Findings show this gene’s expression is dramatically altered in adult animals after coming in contact with an endocrine disruptor for only one day during development.

Moving forward, the scientists will build on the research to test lifestyle interventions, such as diet and exercise, to determine the possibility of resetting the epigenetic programming back to normal, ultimately decreasing the risk of disease.

“Early life development is such a critical time for ‘installation’ of epigenetic programming that is carried with us throughout life,” Walker explained. “This research is a perfect example of the power of team science, which allows us, as experts in our respective fields, to make quantum leaps together to better understand the environmental causes of disease.”

The cross-institutional team also includes Bert O’Malley, M.D., professor and chair, and Michael Mancini, Ph.D., professor, both in the department of molecular and cellular biology at Baylor College of Medicine and Mark Bedford, Ph.D., professor in the department of molecular carcinogenesis at the University of Texas MD Anderson Cancer Center.

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